Omic analysis demonstrated induction of a disease-relevant state enriched for “Diabetes Mellitus Experimental” and “Diabetic Cardiomyopathy” pathways, and known human DbCM biomarkers, such as natriuretic peptide A (electrolyte homeostasis), nebulin (cytoskeleton), and frizzled-related protein (Wnt signaling) (40), robustly clustered control and IR samples. Here, NEB is linked to diabetic cardiomyopathy.