However, it is important to note that the nestin-Cre mice have previously been shown to demonstrate mild hypopituitarism, accompanied by decreased body weight, and to ensure that these results could not be due to the nestin-Cre genotype, we compared their weight to the Nes-Cre+/–Kmt2a+/+ littermates (51). This evidence concerns the gene NES and hypopituitarism.