Nevertheless, the robust functional evidence from the Ndufa/miR147del mouse, which phenocopies miR147-deficient mice in colitis, combined with increased Ndufa4 expression in miR147-deficient IECs and mutually exclusive spatial expression patterns in murine and human colons, strongly supports a regulatory role for miR147 in suppressing Ndufa4 expression to maintain intestinal epithelial homeostasis during inflammation. The gene discussed is COXFA4; the disease is colitis.