To further investigate the role of Gls1 deficiency in T cells in lupus-like autoimmunity, we used the chronic graft versus host disease model (cGVHD), in which an autoimmune response is induced in B6 mice by the transfer of H2-b alloreactive splenocytes from the B6.bm12 strain (46). This evidence concerns the gene GLS and chronic graft versus host disease.