GLS and systemic lupus erythematosus: To investigate the T cell–intrinsic role of glutaminolysis on Tfh cells and to eliminate potential off target effects of DON, we bred Gls1 deficiency on T cells in B6.Sle1b mice, a congenic strain derived from the NZM2410 lupus model carrying mutations in 6 SLAM family genes (28), which functionally regulate Tfh cells and GC B cells (29, 30).