Moreover, increased relative abundance of secondary bile acid-promoting (e.g. Clostridium, Enterococcus and Bifidobacterium) and deleterious (e.g. Escherichia–Shigella and Streptococcus) flora in the intestinal flora of children with CLD was positively correlated with IL-17, leading to increased inflammation and CLD aggravation. The gene discussed is IL17A; the disease is congenital secretory chloride diarrhea 1.