The tetraspanin CD81 is indispensable for the αvβ5 integrin‐dependent particle‐binding step of RPE phagocytosis.[43] PTK2/FAK and PGC‐1α/PPARGC1A is involved in β5 integrin‐mediated POS binding by the RPE.[44] TLR4, TLR6 and COX2 are downstream molecules of CD36 involved in AMD.[45] Compared to NC hTERT RPE‐1 cells, the expression of CD81, PTK2/FAK, TLR4, and TLR6 were noticeably decreased in TRIM49‐depleted hTERT RPE‐1 cells (Figure 5G). This evidence concerns the gene CD81 and age-related macular degeneration.