Besides the STING/TBK1 pathway revealed in this study, recent research has shown that factors such as ADAM9 can modulate the HCC immune microenvironment through regulation of ferroptosis.[46]While previous studies have demonstrated that hyperactivation of this pathway may induce benign liver injury through pro‐inflammatory cytokine release,[47] the pathway activation observed in our study is maintained within therapeutic windows, with its critical contribution to antitumor immunity significantly exceeding potential adverse effects. This evidence concerns the gene TBK1 and hepatocellular carcinoma.