GPX4 and neoplasm: A decrease in glutathione peroxidase 4 (GPX4) levels, coupled with an accumulation of lipid‐reactive oxygen species (ROS), can trigger ferroptosis.[31] Key features of ferroptosis include elevated iron ion concentrations, increased lipid peroxidation, and mitochondrial sequestration.[32] Upon treatment with double‐loaded nanoparticles, a significant rise in ROS accumulation was observed in tumor cells, as evidenced by the DCFDA probe, which measures ROS intensity (Figure 3C,D).