Therefore, the aim of this study was to investigate the effects of combined treatment with trolox, r-irisin and resveratrol on the metabolism of osteoblasts isolated from patients undergoing hip arthroplasty for coxarthrosis or fragility fracture, assessing the potential modulation of key regulators of oxidative stress and mineralization, such as NOX4, SIRT1 and PTX3. Here, SIRT1 is linked to osteoarthritis, hip.