Although disorganized thalamocortical connectivity had never been reported in patients with KIF7 mutation or in patients with ciliopathy, thalamocortical connectivity is essential for cognitive performances in young infants (Alcauter et al., 2014), and its alteration leads to neurodevelopmental delay and later cognitive deficits (Jakab et al., 2020). Here, KIF7 is linked to Cognitive impairment.