Studies have also shown that lactate activation of HCAR1 has a pro‐cancer effect in breast cancer, lung cancer, colon cancer, cervical cancer, and glioblastoma.[34, 35, 36, 37, 38] Based on sarcoma data from the TCGA database and our clinical cohort samples, we consistently observed that high HCAR1 expression was inversely correlated with tumor grade, stage, and survival rates in OS patients, albeit in a single‐center study with a limited sample size. This evidence concerns the gene HCAR1 and cancer.