As shown in Table 2, univariate analysis of AL after esophagectomy showed that BMI, high blood pressure, chronic bronchitis, smoking, diabetes, drinking, peptic ulcer, NACT, coagulation, operation way, anesthesia, the lymph node cleaning number, anastomosis way, anastomotic location, postoperative anemia, postoperative albumin, pulmonary infection, and chylothorax were potential risk factors for anastomotic leakage (p < 0.05). This evidence concerns the gene ALB and diabetes mellitus.