Studies have shown that inflammatory factors such as TNF‐α, IL‐6 and IL‐1β can interfere with amino acid metabolism by activating NF‐κB signaling pathway, especially alanine, aspartate and glutamate metabolism, as well as arginine and proline metabolism, leading to cell dysfunction and promoting the progression of chronic inflammatory diseases such as RA [48, 49]. This evidence concerns the gene TNF and rheumatoid arthritis.