Moreover, DBD significantly downregulated the expression of phosphorylated proteins in both RA‐FLS cells and synovial tissue of rats involved in the NF‐κB signaling pathway, including p‐IκBα, p‐p65, and p‐IKKα, and suppressing NLRP3 protein and mRNA expression of IκBα, p65, and IKKα. The gene discussed is CHUK; the disease is rheumatoid arthritis.