PDGFRA and Cirrhosis: Single-cell approaches and modeling of cell-cell communication potentially enable identification more specific molecules and pathways regulating ECM-producing myofibroblasts (86, 87), for example, PDGF/PDGFRA, TNFSF12/TNFRSF12A, IL-1β/IL-1R1, and AREG/EGFR between scar-associated macrophages (SAMacs) and myofibroblasts or Notch signalling between scar-associated endothelial cells and myofibroblasts in advanced cirrhosis (14).