Overexpression of NR2F1 in the BRAF-V600E 1205Lu, WM793, and A375 melanoma cell lines reduced the tumor growth–inhibiting effects of BRAFi + MEKi by enhancing proliferation, survival, and invasion in vitro while accelerating tumor relapse in vivo, partly through sustained mechanistic target of rapamycin complex 1 (mTORC1) signaling. This evidence concerns the gene NR2F1 and melanoma.