In 3 melanoma cell lines (1205Lu, WM793, and A375), NR2F1 expression induced an enrichment in the hallmark gene sets for MYC targets variant 2 and mTORC1 signaling in the presence BRAFi + MEKi compared with treated control cells that did not overexpress NR2F1 (Figure 4, A and B, and Supplemental Figure 3A). The gene discussed is NR2F1; the disease is melanoma.