NR2F1 and neoplasm: Expression of the orphan nuclear receptor subfamily 2 group F member 1 (NR2F1, also known as COUP-TFI) promotes tumor cell dormancy via induction of SOX9/RAR/TGF/p38-driven quiescence programs in breast and prostate tumor models (27, 28); however, the role of NR2F1 in drug tolerance remains unknown.