In the pan-cancer ICB cohort from the University of Michigan (MI-ONCOSEQ; n = 108; Supplemental Table 1), low pretreatment expression of CDK12/13 (bottom 20th percentile) was similarly associated with improved survival, reaching borderline statistical significance (P = 0.0519; Figure 1C), suggesting that a larger sample size may be required to achieve statistical significance. Here, CDK12 is linked to cancer.