TNF and major depressive disorder: Higher functioning levels may reduce the detrimental effects of inflammation on depression, possibly by supporting better adaptive coping mechanisms and resilience.11 Moreover, regular exercise, which is associated with higher functioning levels, has been shown to reduce baseline TNF-α levels, contributing to its overall anti-inflammatory effects.12 The relationship between functioning levels and inflammatory markers, such as TNF-α, in the context of depression treatment has not been widely explored, but may provide valuable insights.