The PubMed search strategy utilized a combination of relevant keywords and Medical Subject Headings (MeSH) terms. ("Empagliflozin"[Mesh] OR "Sodium-Glucose Transporter 2 Inhibitors"[Mesh] OR empagliflozin[tiab] OR SGLT2[tiab]) AND ("Heart Failure"[Mesh] OR "Cardiovascular Diseases"[Mesh] OR "Diabetes Mellitus, Type 2"[Mesh] OR heart failure[tiab] OR cardiovascular[tiab] OR diabetes[tiab]) AND ("Randomized Controlled Trial"[Publication Type]) NOT ("Kidney Diseases"[Mesh] OR kidney[tiab] OR renal[tiab]). Here, SLC5A2 is linked to diabetes mellitus.