CD8A and mycosis fungoides: Histologically, MF is characterized by dermal infiltration of memory-type helper T cells, which are typically CD3+, CD4+, CD45RO+, and CD8−, as demonstrated through immunohistochemical analysis [3]. CD4 and CD8 are surface glycoproteins that define functionally distinct subsets of T-lymphocytes: CD4+ cells act as helper T cells, while CD8+ cells are cytotoxic.