Subsequently, we conducted RNA-seq and LC-MS/MS analyses to identify differentially expressed genes and proteins in SH-SY5Y neuroblastoma cells treated with amisulpride.<h4>Results</h4>In the present study, we used RNA-seq analysis to identify downregulated expression of a transcriptional factor, <i>FOSB</i>, in amisulpride-treated SH-SY5Y neuroblastoma cells, while using LC-MS/MS analysis to identify multiple differentially expressed proteins in these cells. Here, FOSB is linked to neuroblastoma.