Additionally, study on type 1 diabetic nephropathy have shown a correlation between elevated KDM6A levels and worsened renal tubular dysfunction and tissue damage, with miR-199b-3p downregulation accelerating the epithelial-to-mesenchymal transition process by influencing KDM6A and E-cadherin expression.37 Here, KDM6A is linked to type 1 diabetes nephropathy.