VEGFA and Stroke: We initiated EV treatment 7 days following tMCAO, a timepoint chosen based on a strong biological rationale: (1) NSC proliferation peaks at 7 to 14 days post‐stroke [41], (2) angiogenesis begins within hours of stroke onset, also peaking at 7 to 14 days after stroke [15, 42], and (3) VEGF should be applied at least 48 h after stroke to avoid adverse effects like BBB leakage [43, 44, 45].