We hypothesize that the combination of targeted delivery, via RGD surface functionalization, with enhanced therapeutic cargo loading, via SLO‐mediated VEGF encapsulation, will synergistically improve accumulation of NSC‐EVs in ischemic brain regions and amplify their neuroregenerative effects, offering a novel and clinically translatable therapeutic strategy for ischemic stroke. This evidence concerns the gene VEGFA and ischemic stroke.