Based on the logistic regression model, the most influential predictors of high IIP‐D group were frontal bossing (10.7), palpitations (1.01), cardiomyopathy (0.73), disease duration (0.70), preoperative GH concentration (0.65), acral enlargement (0.60), arrhythmia (0.55), and atrial fibrillation (0.48) (Figure 2A). The gene discussed is GH1; the disease is cardiomyopathy.