Identification of various TAM subsets in these studies, with datasets of more than 10 cancer types, illustrated a comprehensive phenotypic map of TAM; for example, C1QC+ TAMs, LYVE1+ TAMs, TREM2 TAMs and IL4I1 TAMs, which were suggested to be correlated with cancer development via different mechanisms [27, 75]. This evidence concerns the gene IL4I1 and cancer.