RHOT1 and Parkinson disease: Fibroblasts from familial PD patients (Ratio 0.89 ± SD 0.1) P < 0.0001, including those with PINK1/PRKN/LRRK2 mutations (Ratio 0.93 ± SD 0.1) P < 0.0001 exhibited the strongest Miro1 retention ratio in contrast to healthy controls (Ratio 0.5 ± SD 0.1) (Fig. 1D).