By concurrently suppressing the pro-inflammatory and pro-fibrotic ROCK1 and TGF-β1 pathways, downregulating the lipogenic SREBP-1c pathway, and more potently activating the central metabolic regulator AMPK, cranberry extract provides a more comprehensive approach to ameliorating the multifaceted organ dysfunction characteristic of MetS. The gene discussed is TGFB1; the disease is metabolic syndrome.