RHOA and metabolic syndrome: The following discussion delves more deeply into the multifaceted protective actions of cranberry vs. metformin on hepatic and renal health in a metabolic syndrome rat model, exploring the interconnected mechanisms through which both interventions modulate key pathways, such as the AMPK, RhoA/ROCK, and Srebf1 pathways, to improve metabolic function, reduce fibrosis, and ultimately preserve organ integrity.