SIRT1 and obesity due to melanocortin 4 receptor deficiency: This result came in agreement with Heo MyeongGang and Choung SeYoung75 and Radwan, et al.35who reported the ability of n-hexadecanoic acid and L-car to relieve high-fat diet-induced obesity and methotrexate induced nephrotoxicity through upregulation of SIRT1, respectively.