Similarly, in HCT116 colon cancer cells treated with dehydroepiandrosterone (DHEA), co‐treatment with 1 mM 4‐PBA markedly reversed DHEA‐induced upregulation of ER‐stress markers GRP78, phosphorylated PERK, ATF4, and CHOP, concomitantly attenuating downstream apoptotic effectors DR5 and PUMA as well as the cell‐cycle arrest marker p21 [19]. This evidence concerns the gene DDIT3 and colonic neoplasm.