In HT‐29 colon cancer cells, 4‐PBA has been shown to induce significant growth inhibition and apoptosis through the inactivation of the NF‐κB (p50:p65) heterodimer, implicating modulation of ER‐stress as a key driver of its proapoptotic effects [18]. This evidence concerns the gene NFKB1 and colonic neoplasm.