Here, we investigated mice with a conditional knock-in of PDGFRβ hyperactivation using a Fsp1, also known as S100A4, promoter (Fsp1-cre;Pdgfrb<sup>+/D849V</sup>), which consistently develop cataracts at a young age.<h4>Methods</h4>Lenses from Fsp1-cre;Pdgfrb<sup>+/D849V</sup> mice and age-matched controls were dissected and visualized via microscopy from 9 to 15 weeks. Here, S100A4 is linked to cataract.