APOL2 and cancer: Amongst the several abnormal genes that have been reported as potential prognostic biomarkers for GC as they play important roles in its development and progression,[30] APOL2 has been implicated in cancer invasion and metastasis.[21] In addition, some studies have revealed that APOL2 regulates tumor cell proliferation, apoptosis, and drug resistance.[18] Nonetheless, research specifically focusing on APOL2 in GC is lacking.