Additionally, to rule out potentially confounding effects of the Ins2‐Cre transgene, SCAMP5‐deficiency‐induced glucose intolerance was further evaluated in Scamp5flox/flox‐Ins2‐Cre and Scamp5flox/+‐Ins2‐Cre mice (Figure S2B, Supporting Information), and corroborated by findings obtained from tamoxifen‐induced β‐cell‐specific Scamp5 knockout mice (Scamp5flox/flox‐Pdx1‐Cre) and control mice (Figure S2C, Supporting Information). Here, PDX1 is linked to Glucose intolerance.