STAT3 and Sepsis: First, the reliance on murine models (CLP and LPS) restricts direct translation to human sepsis, which exhibits greater etiological and immunological heterogeneity.[61, 62, 63, 64] While plasma P‐RIPK1 levels correlated with disease severity in sepsis patients, direct evidence of the JAK1‐STAT3‐CXCL1 axis in human lungs remains to be established.