WNK2 and neoplasm: By analyzing the phosphoproteome of the tumor tissues, we identified that pro-oncogenic pathway proteins such as mammalian target of rapamycin (mTOR) and mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) were highly phosphorylated at p-mTORSer2448 and pP44/42Thr202/Tyr204 sites, respectively, particularly in Response 2 (SI Appendix, Fig. S5D).