The dual role of JNK2 in tumor biology is well-documented-it can either promote proliferation or induce apoptosis depending on cellular context [12].We speculate that in CD95-expressing colorectal cancer cells, JNK2 primarily sustains proliferative signaling, while in CD95-deficient cells, JNK2 preferentially activates cell death pathways. This evidence concerns the gene MAPK9 and colorectal cancer.