PDGFB/PDGFRB signaling has been associated with fibrosis; for example, constitutive activation of PDGFRB in mesenchymal cells has been shown to result in spontaneous renal fibrosis (49), while inhibition of PDGFB or PDGFRB has reduced fibrosis in experimental CKD models (50–56). Here, PDGFRB is linked to chronic kidney disease.