TEK and Sepsis: Notably, ABTAA offered greater protection in sepsis compared with ANGPT2 inhibition alone (39), highlighting its dual beneficial effects: (a) the removal of ANGPT2’s antagonistic activity on TIE2 and (b) the enhanced TIE2 signaling through the conversion of ANGPT2 into a higher-order oligomer that effectively activates TIE2 (39).