BRCA1 and breast cancer: Here, African American or Black women with breast cancer were approximately 1.74 times as likely as White women (OR, 1.74; 95% CI, 0.91-3.36) to carry a P/LP germline mutation in either BRCA1 or BRCA2. However, this increase in risk does not reach a nominal threshold of statistical significance, and 95% CIs include the null hypothesis of no association (OR = 1.00).