F5 and Stroke: The 20% of patients without risk-enhancing features (median RoPE-score of 7, IQR 6–8) were accepted for PFO closure for various reasons: a high RoPE-score (21 patients), absence of an alternative cause of stroke (10 patients), multiple stroke events (7 patients), recurrent event despite antithrombotic therapy (2 patients), presence of Factor V Leiden without an alternative cause (2 patients), antiphospholipid syndrome without an alternative cause (1 patient), and occupation-related risk (1 patient; a flight attendant with a possible increased risk of stroke recurrence).