STAT3 and cancer: The oncogenic potential of STAT3 is widely recognized through its role in regulating the expression of genes associated with cancer cell tumorigenic behavior, chemoresistance, immune suppression, stem cell self-renewal, and maintenance [16, 17]; STAT3 is overexpressed and constitutively activated and strongly associated with tumor initiation, progression, metastasis, chemotherapy resistance, and poor survival rates [18].