It has been suggested that interactions may be cell type-specific [72]; for example, in esophageal squamous cell carcinoma, STAT3 is influenced by the β-catenin/T-cell factor pathway [73], while in breast cancer, STAT3 may directly regulate β-catenin transcription, demonstrating a potential synergy in their oncogenic roles [74]. The gene discussed is STAT3; the disease is esophageal squamous cell carcinoma.