Proinflammatory cytokines associated with T cell responses were significantly increased by anti‐CD3/CD28 in both tissue types after stimulation, as evidenced by a significant increase in IFNγ (non‐tumor: 1,368‐fold; tumor‐border:149‐fold), IL‐2 (non‐tumor: 432‐fold; tumor‐border: 78‐fold), Granzyme B (non‐tumor: 180‐fold; tumor‐border: 7.6‐fold), TNFα (non‐tumor: 105‐fold; tumor‐border: 7.9‐fold), and IL‐17A (non‐tumor: 62‐fold; tumor‐border: 57‐fold). Here, IL2 is linked to neoplasm.