Among the previously known and here confirmed interactors (CDH1, DISP1, SCFD1, USE1, TSG101, and USP8), CDH1 (E‐cadherin), a critical adhesion molecule, is frequently lost or downregulated in pancreatic cancer, promoting epithelial‐to‐mesenchymal transition (EMT) and enhancing tumor invasiveness (Saito et al. 2017; Micalizzi et al. 2022). Here, USE1 is linked to familial pancreatic carcinoma.