KCNN4 and pancreatic ductal adenocarcinoma: Given that high integrin β4 expression was shown to promote epithelial‐mesenchymal transition, stabilize filopodia and represents a prognostic marker in pancreatic ductal adenocarcinoma (Masugi et al. 2015), we tested whether filipodia formation was increased upon overexpression of the interacting KCa3.1 channel, showing that overexpression of the channel in KPCY cells led to actin cytoskeletal remodeling, characterized by multiple filopodial extensions and well‐defined stress fibers (Figure 5C).