KCNN4 and neoplasm: Moreover, PDAC cells rely on metabolic flexibility, and mitochondrial KCa3.1 may facilitate adaptive metabolic shifts (Yamamoto et al. 2022): by supporting oxidative phosphorylation (OXPHOS) and mitochondrial efficiency, KCa3.1 can help PDAC cells to survive in a hypoxic tumor microenvironment (Kovalenko et al. 2016; Sadozai et al. 2024).