KCa3.1 contributes to potassium flux across the mitochondrial inner membrane, helping to stabilize the mitochondrial membrane potential (ΔΨm), which is crucial for regulating several mitochondrial processes, therefore supporting pancreatic ductal adenocarcinoma (PDAC) growth (Hashimoto et al. 2022, Decker and Funai 2024). The gene discussed is KCNN4; the disease is pancreatic ductal adenocarcinoma.