In the present study, we used as the parental model KPC cells that originate from the KPC (Kras^G12D/+; Trp53^R172H/+; Pdx1−Cre) genetically engineered mouse model (GEMM) of PDAC, a system that closely recapitulates the aggressive and metastatic behavior of human pancreatic cancer. This evidence concerns the gene TP53 and familial pancreatic carcinoma.