Interestingly, disruption of Orai1‐SK3 interaction in the rafts was shown to limit metastatic spread of breast cancer cells (Girault et al. 2011; Guéguinou et al. 2014), and STIM1 was found to be located not only in the ER but also in the plasma membrane (Debant et al. 2019). Here, ORAI1 is linked to breast cancer.