IARS2 is a mitochondrial Isoleucyl‐tRNA synthetase, while AHCYL1 is an adenosylhomocysteine hydrolase‐like protein 1, whose expression was proposed to be considered as a novel biomarker for predicting prognosis and immunotherapy response in colorectal cancer (Li et al. 2022). This evidence concerns the gene AHCYL1 and colorectal cancer.