Furthermore, RNA dysregulation is a key contributor to ALS pathology, and multiple ALS associated genes such as SOD1, TARDPB (encoding TDP‐43), and C9ORF72 can participate in RNA metabolism including RNA transcription, RNA splicing, RNA transport, and RNA stabilization (Butti and Patten 2018). The gene discussed is C9orf72; the disease is amyotrophic lateral sclerosis.