The fact that in AD, the LC starts accumulating p-Tau decades before the onset of cognitive impairment (Braak et al., 2011), and that in Parkinson's disease, LC disintegration is related to dysautonomia (Madelung et al., 2022), which is associated with faster disease progression (De Pablo-Fernandez et al., 2017), suggests a relevant role of the link between the LC and circadian BP in the etiology and progression of neurodegenerative diseases. Here, MAPT is linked to neurodegenerative disease.