In the same manuscript, scientists pointed out how snRNAs dysregulation can shape the global transcriptome of breast cancer and contribute to tumorigenesis itself: U1 and U5A were abundantly found in HER2+ BC subtype, whereas the two clusters of triple-negative analyzed samples showed a higher relative presence of U6 and comparatively low levels of U2 and U5A. Undoubtedly, further work is required to determine their effective contribution to the definition and/or regulation of each subtype (162). This evidence concerns the gene ERBB2 and breast cancer.