NBAT1 and breast cancer: Another important example of the contribution of the lncRNAs in breast cancer metastasis formation is represented by neuroblastoma-associated transcript 1 (NBAT1) (57), and by the aforementioned HOTAIR. The former induces BC cells invasiveness by reducing H3K27me3 levels, while the latter induces migration and invasion by recruiting the polycomb repressive complex 2 (PRC2) which leads to the variation of H3K27 methylation levels and global gene expression alterations (58).