For example, hypoxia-inducible factor 1α (HIF-1α) upregulates MALAT1 with the mediation of AMP-activated protein kinase (AMPK) (51); the induced lncRNA then acts as a miRNA sponge of miR-3064-5p, a mechanism that promotes tumor growth and migration in breast cancer cells (52). This evidence concerns the gene MALAT1 and breast cancer.