CD4 and primary central nervous system lymphoma: The incidence of PCNSL is inversely correlated with CD4 cell count, with a notable decline in the incidence in PLWH treated with combination ARV.11,12 The mean CD4 T-lymphocyte count in 10 of the 14 HIV-positive patients in our series was 107 cells/μL, with a median of 91.5 cells/μL.