Abnormal fat deposition in the liver and obesity lead to pro‐inflammatory mediators such as TNF‐α, IL‐6, and IL‐8, and reduce the synthesis of anti‐inflammatory factors such as IL‐10 and adiponectin (Anjum et al. 2024; Stojsavljević et al. 2014). Here, TNF is linked to obesity due to melanocortin 4 receptor deficiency.