CXCL8 and obesity due to melanocortin 4 receptor deficiency: Abnormal fat deposition in the liver and obesity lead to pro‐inflammatory mediators such as TNF‐α, IL‐6, and IL‐8, and reduce the synthesis of anti‐inflammatory factors such as IL‐10 and adiponectin (Anjum et al. 2024; Stojsavljević et al. 2014).