IL13 and obesity due to melanocortin 4 receptor deficiency: Moreover, in patients with relapsing–remitting MS, obesity has been associated with an amplified central inflammatory response, as evidenced by elevated cerebrospinal fluid concentrations of the pro‐inflammatory cytokine interleukin‐6 (IL‐6) and diminished levels of the anti‐inflammatory cytokine interleukin‐13 (IL‐13) (Stampanoni Bassi et al. 2020).