Potential mechanisms include: (1) Hypercholesterolemia may promote uric acid retention by upregulating renal urate reabsorption proteins (such as URAT1) (12, 13); (2) Oxidative stress and inflammation driven by abnormal TC may damage renal tubular function (14); (3) Cholesterol crystal deposition may directly cause renal interstitial injury (15). The gene discussed is SLC22A12; the disease is familial hypercholesterolemia.