Prediction models considering not only SIRI but also other factors involved in the previously published data including cystatin-C, serum ALB, HGB, 24-hour urinary protein, albuminuria, Scr, baseline eGFR, serum transferrin, SUA, serum bilirubin, blood pressure and drug administration (43–47) would increase the sensitivity and specificity of prediction model in predicting renal function decline in T2DM patients. The gene discussed is CST3; the disease is type 2 diabetes mellitus.