The comparison of positive area percentage showed that the expression level of OPN (0 days: p = 0.01, 3 days: p = 0.03, 6 days: p = 0.01, 9 days: p = 0.01, 12 days: p < 0.001), RANK (0 days: p = 0.03, 3 days: p = 0.01, 6 days: p = 0.01, 9 days: p < 0.001, 12 days: p < 0.001), and RANKL (0 days: p = 0.01, 3 days: p = 0.02, 6 days: p = 0.002, 9 days: p < 0.001, 12 days: p < 0.001) protein in the diabetes group was significantly higher than that in the control group, as shown in Figure 5. The gene discussed is SPP1; the disease is diabetes mellitus.