For DFS, univariate Cox analysis showed that positive CLDN18.2 expression (HR = 1.865, 95% CI = 1.053-3.304; P = 0.033), large tumor size, serum CA19–9 elevation, advanced TNM stage, poor histological grade, MVI and lymph node metastasis were all significantly associated with disease recurrence. This evidence concerns the gene CLDN18 and neoplasm.