For DFS, univariate Cox analysis showed that positive CLDN18.2 expression (HR = 1.865, 95% CI = 1.053-3.304; P = 0.033), large tumor size, serum CA19–9 elevation, advanced TNM stage, poor histological grade, MVI and lymph node metastasis were all significantly associated with disease recurrence. The gene discussed is CLDN18; the disease is metastatic malignant neoplasm in the lymph nodes.